September 29, 2016

Mixing dynamics in a large volume single use mixer

Large volume single-use technology mixers can be used for mixing operations throughout the entire bioprocess  workflow. Large-volume mixers are mainly required in clinical three-scale and production-scale facilities where  mixing efficiency is one of the key drivers of throughput efficiency. Upstream applications such as medium  preparation and harvest require fast and efficient mixing whereas downstream mixing operations used in  purification and separation processes require sensitive mixing.
Dispersion and settling were evaluated as part of this study, which provides a clear decision path on the tank shape  and impeller quantity for a given impeller design and a given impeller location. Dissolution studies will be used in  the future to understand the liquid-liquid and powder-liquid mixing times along with zone mapping and test validation.

Download the application note.

Tags: CFD, impeller, mixing, bioreactor, upstream