September 16, 2013

Process scale-up from HiScreen™ to HiScale™ columns


In this study two capture purification steps were scaled up from HiScreen to HiScale columns in order to evaluate
process reproducibility and robustness. The two media used, MabSelect SuRe™ and Capto™ Q showed strong reproducibility and high yield (> 96%) during scale-up, demonstrating the excellent performance and consistency of HiScreen and HiScale columns as well as the BioProcess™ media.

Tags: process development, Capto, Mabselect sure, Mab, purification, scale-up