June 6, 2019

Scale-Up Model of a mAb Process from Microbioreactor to XDR-1000


posterIn process development, it is desirable to test process parameters in small scale and later scale up the process into larger production scale. A theoretical scale-up study was performed on a mAb process based on physical characterizations done on the Xcellerex XDR platform, from micro reactors up to large production-sized reactors. All investigated bioreactor systems displayed similar trends over time and acceptable variability between cultures for viable cell density and viability profile, product titer, lactate, and product quality. 

For more details, download the scientific poster. 

Tags: antibody production, CHO, process development, scale up