June 6, 2019

Scale-Up Model of a mAb Process from Microbioreactor to XDR-1000


In process development, it is desirable to test process parameters in small scale and later scale up the process into larger production scale. A theoretical scale-up study was performed on a mAb process based on physical characterizations done on the Xcellerex XDR platform, from micro reactors up to large production-sized reactors. All investigated bioreactor systems displayed similar trends over time and acceptable variability between cultures for viable cell density and viability profile, product titer, lactate, and product quality.

Tags: antibody production, CHO, process development, scale up