September 23, 2013

A novel AIEX chromatography medium (resin) to remove IgA and IVIG purification process

A novel AIEX chromatography medium (resin), Capto™ Q XP, was designed by CDM, GE Healthcare Life Sciences, based on a large pore high-flow agarose base matrix modified with conventional strong anion exchange groups to optimize the adsorption of large molecular weight proteins. The dynamic binding capacity and pressure-flow properties were the key attributes considered when screening different prototypes during the development work. 

The goal of this work was to develop a robust industrial scale IVIG process allowing for high purity, yield and productivity.

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