January 10, 2016

A rapid and efficient approach to media and feed optimization increasing CHO antibody production


Different CHO clones have been shown to exhibit a large degree of variability when it comes to their nutritional needs and requirements. As a result, every transfected CHO cell line can have a unique set of nutritional requirements for maximizing cell growth and recombinant protein production. Therefore, it is essential to develop an optimal basal medium and feed formulation in the most efficient manner possible. In this study, a well-balanced variety of methods were able to optimize and formulate a chemically-defined cell culture medium and feed for recombinant CHO cell suspension culture.

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