July 13, 2016

High protein concentration UV sensing in bioprocess applications

Increased titers in cell culture, increased capacity of chromatography resins, and UF/DF operations with concentrations beyond 200g/L in combination with stronger demands on process understanding/PAT put new demands on UV-Vis absorption sensing in bioprocess applications.

We present devices, concepts, and results that can address those challenges. By using UV flow cells with different path length in series, many different options are available and multiple needs can be addressed. The flow cells can be adapted to flow ranges from lab- to large-scale production equipment.

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