January 18, 2019

High-Throughput Downstream Processing Using Cellulose Fiber Chromatography and ÄKTA™ Chromatography Systems

Developing a process or looking for a clone of interest often requires screening large numbers of samples. Many analyses require purified proteins, and often substantial hands-on time is required for purification. The novel cellulose fiber technology (known as Fibro) may be used with ÄKTA chromatography systems and autosamplers to reduce process time significantly compared with conventional chromatography. Fibro chromatography enables residence times of seconds, with full chromatographic runs in a few minutes per cycle. Here, we describe a versatile solution that significantly increases throughput by completing the purification process in minutes rather than hours.

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