April 5, 2017

In-line conditioning using ready-made stock solutions in a mAb process step


Buffer preparation in the biopharmaceutical industry can be challenging. One trend is in-line dilution of buffer concentrates to reduce the floor space for buffer preparation/storage as well as to enable the use of bags for the buffer concentrates. The in-line conditioning (IC) technique addresses both the floor space issue as well as the complexity and inherent variability in buffer preparation. Single-component stock solutions of salt, acid and base are mixed and diluted with water to formulate the desired buffer.

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