August 10, 2017

Mixing and Temperature Characterization of Single-Use Mixing Systems

Single-use mixing systems are widely used in biomanufacturing due to the many advantages that come with disposables, including reduced cross-contamination risk and shorter batch changeover time. The main challenge when transferring biotherapeutic production processes from stainless-steel to single-use vessels is insufficient knowledge about the physical performance of the equipment. In this study, heating/cooling properties, as well as liquid-liquid and solid-liquid mixing times were characterized for various volumes and impeller speeds in the Xcellerex™ XDM/XDUO 50, 100, 200, and 500 L mixers to confirm homogenous mixing and sufficient heat transfer capacity.

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