December 6, 2018

Process Economy Impact of Protein A Resin Alkaline Stability


The design of a monoclonal antibody (mAb) capture step is strongly dependent on economic considerations influenced by factors such as scale, number of batches per year and resin lifetime. This poster presents a process economy simulation comparing three protein A chromatography resins with the aim to demonstrate the influence of dynamic binding capacity (DBC) and alkaline-stability of the resin for process economy.

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