April 6, 2017

Process economy modeling for viral vector production

Viral vectors, such as adenovirus, adeno-associated virus, and herpes simplex virus, can be used in cancer therapeutics and in vaccines for chronic diseases and are thus expected to become high-value products. Cost-efficient production is important and should be considered early in development. Obtaining a safe and efficacious product that can be produced at a competitive cost is a balance between required purity, yield, throughput, and productivity. Traditionally, process development starts with evaluation of different unit operations in small scale, with main focus on performance and less on cost-efficiency. Here we used an alternative strategy: start with process economy calculations, and let the outcome guide to which unit operations would be economically feasible, and should be the primary focus of the experimental evaluations.

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