October 28, 2013

Purification strategies and platform alternatives for monoclonal antibodies


Platform approaches to downstream purification of MAbs have become generally established. Continuous improvement of these platforms with new chromatographic media with for example higher capacities and/or better selectivity constantly occur.  Protein A chromatography media is commonly used as capture because of its robustness and high purity in the elution pool. The remaining impurities are being removed by either one or two polishing steps. In this work we present data from two purification platform processes, one 2-step and one 3-step process.

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