May 31, 2017

Scientific strategy for resin selection and single-use film architectural design for cell culture systems

The design of a next-generation film for use in biomanufacturing requires optimization for a wide range of applications, from medium storage to bioreactors. Key to this endeavor are the areas of mechanical properties, physical properties, and biocompatibility to achieve desired performance. However, over the past several years, material of construction has been an area of focus due to observations of negative impact of extractable compounds from bioprocess film on the growth of certain sensitive cell lines. As a result, the industry is now advancing toward developing single-use films that are better suited to fit the needs of biomanufacturing. To further address biocompatibility, growth studies of cell culture medium stored in multiple lots of Fortem™ film ReadyToProcess™ bags were performed.

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