In today's bioprocessing industry, there is a demand to cut manufacturing costs while maintaining product safety and quality. Additionally, flexibility needs to be increased and time to market reduced. Upstream processes are more efficient and product higher titers than before. With these improvements, new challenges arise. Downstream processes have to handle higher amounts of both targetprotein and impurities. So, in order to make full use of upstream advances in an efficient manner, it is essential that downstream processes are intensified.
This white paper covers methods of improving downstream operations through process intensification. It describes techniques like continuous processing and in-line conditioning buffer preparation, system automation, and more. It also shows how implementation of efficient process designs can overcome traditional downstream bottlenecks, such as time-consuming column packging, cleaning of equipment, and laborious buffer tank farms.