August 10, 2017

Virus Production in Single-Use Bioreactor Systems Using Pre-Sterilized Microcarriers

Since the 1980s, microcarriers have been used to provide growth support for adherent cells in vaccine biomanufacturing processes at scales up to 6000 L. Today, as yields are increasing, most newly developed vaccines are manufactured at smaller scales, making single-use technologies suitable.
By using ready-to-use Cytodex Gamma microcarriers, the time-consuming step of microcarrier preparation and sterilization prior to culture was removed. Instead, the microcarriers could be added directly to the bioreactor. Results show comparable results between pre-sterilized Cytodex Gamma and Cytodex microcarriers. 

View Presentation