Search results for " antibody"
Article
Witnessing Major Growth in Next-Generation Antibodies
The global market for next-generation antibodies, including antibody drug conjugates (ADCs), engineered antibodies, bispecific antibodies, antibody fragments, antibody-like proteins and biosimilar ant…
Article
Antibody Production in Microbial Hosts
Therapeutic mAbs and their derivatives—such as antibody fragments (Fab), single-chain Fv (scFv), and diabodies—represent the fastest-growing class of approved therapeutic proteins because of their hig…
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Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
To date, the majority of monoclonal antibodies (mAbs) have generally targeted a particular antigen; however, there are several additional antibody formats currently in the development pipelines of pha…
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Single-Domain Antibodies for Brain Targeting
Smaller recombinant antibody fragments as single-domain antibodies (sdAbs) are emerging as credible alternatives because of their target specificity, high affinity, and cost-effective recombinant prod…
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Generating a Fully Processed Antibody
… performed by Chinese hamster ovary (CHO) cells, and more recently, numerous different multispecific antibody platforms. Each of these classes of molecules requires multiple proteins to be expressed …
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HT Multi-Product Liquid Chromatography for Characterization of Monoclonal Antibodies
Samples containing antibodies in cell culture fluid were injected onto a Protein A column for antibody recovery, then the purified antibody sample was automatically injected onto the size exclusion co…
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The Development and Application of a Monoclonal Antibody Purification Platform
Recent advances in mammalian cell culture technology have resulted in significant increases in upstream productivity, with antibody titers of >5 g/L becoming increasingly common. Such increases could …
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Chromatography for the Diversified Antibody Pipeline
Jeanne Linke Northrop: How is the development we have seen in the antibody therapeutics area effecting chromatography capture that are used in antibody processing?
Eva Helding: The advantage…
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Comparing Protein A Resins for Monoclonal Antibody Purification
With greater economic pressure on monoclonal antibody (mAb) production for therapeutic and research uses, antibody titers in mammalian cell culture have increased dramatically over the past 20 years. …
Article
Top Tips for Successful Development of Antibody Chromatography Processes
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Transcript
Jeanne Linke Northrop: Hello, I…