Search results for " DoE" in Articles / App Notes
Article
DoE Provides Benefits, but Preparation Is Necessary
In addition, a DoE-driven approach meets the International Conference on Harmonization Q8 guidelines for multivariate design space and the subsequent justification of formulation components when devel…
Article
Determining Criticality, Part Two: DoE and Data-Driven Criticality
More complex DOE designs and strategies may be required, but these designs are typical:
• Screening (fractional factorial, Plackett-Burman). To identify or screen out process parameters t…
Article
How to program, run and evaluate a design of experiments (DoE)
Martin Sichting, Product Manager Lab Scale Chromatography Systems at Cytiva, guides you through the DoE process.
You’ll learn how to program, run, and evaluate a design of experiments (DoE) run. An…
Article
Benefits of DoE vs mechanistic modeling
Hear about the main differences between mechanistic modeling and design of experiments when used during chromatography process development. You will learn that, quite often, these methods work…
Article
Design of Experiments for Analytical Method Development and Validation
Recently, more attention has been placed on applying DOE to analytical methods. DOE for analytical methods has three major applications: method development for new methods or those that need improveme…
Article
Mechanistic Modeling: Does it Have a Future in Process Development?
Mechanistic models are considered as an alternative to a standard DoE type empiric approach. Most often, the DoE approach is preferred based on a cost-benefit evaluation where the time consumption, co…
Article
Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
Leveraging the power of HTPD and DoE for chromatographic optimization
The goal in HTPD is to evaluate numerous factors or conditions in parallel using micro-scale formats. It reduces experimental …
Article
Handbook: Design of Experiments in Protein Production and Purification
In a protein research lab or during process development, a DoE approach can greatly improve the ef ciency in screening for suitable experimental conditions, for example, for cell culture, protein sepa…
Article
Robust Optimization, Simulation, and Effective Design Space
Once the DOE is complete, the developer can use the DOE to build a process model, define the design space, and run simulations for various optimums and to determine effective factor ranges where the o…
Article
Essentials in Establishing and Using Design Space
DOE design and scale considerations in the DOE
DOE generation needs to be linked to the risk assessments and business objectives. Full-factorial or D-Optimal custom designs are most comm…