Search results for " large scale buffer management"

Article Downstream Processing for Cell-Based Therapies
By Qasim A. Rafiq, Fernanda Masri With increasing numbers of advanced therapies—including cell and gene therapies—entering early- and late-stage clinical development, significant focus has been …

Article Single-Use for Downstream Chromatography: Benefit or Hindrance?
Single-use technology is gaining ground in downstream bioprocessing, but challenges stall further adoption. By Feliza Mirasol ARTMOIS/STOCK.ADOBE.COM Biopharmaceutical manufactu…

Article A Plastic Pipeline for Commercial Bioprocessing?
A Plastic Pipeline for Commercial Bioprocessing? The maturation of single-use technologies presents commercial bioprocessing options for small-volume drug products. By Rita C. Peters …

Article SEC in the Modern Downstream Purification Process
Mar 01, 2015 By R. Christopher Manzari, J. Kevin O'Donnell BioPharm International Volume 3, Issue 28 Since the introduction of commercial chromatography resins approximately six de…

Article Designing a Biomanufacturing Facility Incorporating Single-Use Technologies
Asking the right questions is crucial to establishing a facility design. By Peter Genest, John Joseph The benefits of adopting single-use technologies in the production of biopharmaceuticals…

Article QbD and PAT in Upstream and Downstream Processing
To gain perspective on the implementation of quality by design (QbD) and process analytical technology (PAT) in biopharmaceutical processing, BioPharm International spoke with Clinton Weber, as…

Article Mixed-Mode Chromatography in Downstream Process Development
Salt-tolerant adsorption and unique selectivity are the major advantages of mixed-mode materials over single-mode resins. By Felix Oehme, PhD, and Joerg Peters, PhD ABSTRACT Mixed-mode chroma…

Article Reducing Cross-Contamination Risks in Process Chromatography
Reducing Cross-Contamination Risks in Process Chromatography Single-use systems provide replaceable fluid paths. By Cynthia A. Challener Fa…

Article Continuous Manufacturing: A Changing Processing Paradigm
Apr 01, 2015 By Randi Hernandez BioPharm International Volume 28, Issue 4 Although continuous manufacturing is well established for bulk chemicals, complex automation and validation …

Article Optimizing Resin Performance with Disposable Chromatography Solutions
Although the initial uptake of single-use chromatography solutions has been relatively slow, an increased need for higher-capacity resins and the demand for smaller batches has made disposable chrom…

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