Search results for " mechanistic modeling"

Article Mechanistic Modeling of Preparative Ion-Exchange Chromatography
For complex unit operations such as process chromatography, mechanistic modeling can assist in developing a systematic approach for process development, monitoring, and control. Models can also be jud…

Article Mechanistic Modeling: Does it Have a Future in Process Development?
Most often, the DoE approach is preferred based on a cost-benefit evaluation where the time consumption, complexity, and lack of know-how on how to deploy are found too extensive when using mechanisti…

Article Mechanistic Modeling: Current Advantages and Future Opportunities in Biopharmaceutical Process Development
This week, Bioprocess Development Forum spoke with Tobias Hahn, PhD, co-founder and CEO of GoSilico, about the opportunities of mechanistic modeling in bioprocess development, now and in the future. …

Article Insider Recommendations for Getting Started with Mechanistic Modeling of Chromatography
Topics covered include: 0:45 - What is mechanistic modeling of chromatography? 3:47 - Obstacles to implementing mechanistic modelling. 5:10 - Top tips for implementing mechanistic modeling

Article Utilization of Mechanistic Modeling to Improve Process Development
Utilization of mechanistic modeling of unit operations, based on scientific and physical understanding of the process, is one of these approaches. Improved computational resources in the past decade h…

Article Advanced therapeutics process development using mechanistic modeling
what the challenges are in process development when working with both diverse molecules and mechanistic modeling. MORE Q&As WITH INDUSTRY LEADERS >>

Article Mechanistic vs Statistical Models
Mathematical models are recommended by the ICH Q8 guidelines on pharmaceutical development to generate enhanced process understanding and meet Quality-by-Design (QbD) guidelines. Read on the d…

Article Developing a Robust Bioprocess Using Mechanistic Models
The safety and efficacy of a biopharmaceutical drug are of the highest priority. Therefore, manufacturers have to design, implement and maintain measures to ensure that the bioprocess con…

Article Engage a mechanistic modeling expert – or become one
The application of mechanistic modeling requires expertise for effective use. When planning to implement this ground-breaking technology one essential question must be addressed befor…

Article Mechanistic chromatography modeling in practice
Access insider recommendations for getting started with mechanistic modeling of chromatography, but also case studies and scientific publications. ACCESS THE RESOURCE HUB >>…

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