Search results for " resins"
Article
Re-use of Protein A Resin: Fouling and Economics
Recent innovations in Protein A-affinity chromatography have targeted creation of new resins capable of delivering high dynamic binding capacity and high throughput with better mass-transfer propertie…
Article
Enhancing Resins Addresses Purification Concerns
Affinity chromatography resins such as oligo(dT) can be used as a capture step, but these resins are not able to separate single-stranded RNA (ssRNA) from double-stranded RNA (dsRNA), and they have a …
Article
Comparing Protein A Resins for Monoclonal Antibody Purification
As a consequence, downstream processing must accept and handle higher titers of mAbs in harvested cell-culture fluid (HCCF), and vendors of mAb purification technologies must develop chromatography re…
Article
Innovative Chromatography Resins Can Improve Purity and Quality
Recent advances in chromatography resins can effectively impact the purification unit operation with positive consequences that reverberate both upstream to the bioreactor and downstream to filtration…
Article
Optimizing Resin Performance with Disposable Chromatography Solutions
In addition, looking at ways to improve on Protein A technology, we are investing in the development of newer-affinity resins (including affinity resins based on Protein L) for the purification of a n…
Article
Development and Future of Protein A Chromatography Technology: Q&A with Jonathan Royce, Business Leader Chromatography Resins, Cytiva
Although Protein A resins introduced to the market in the last 10 years withstand low to medium concentrations of sodium hydroxide for cleaning, like 0.1 M sodium hydroxide and in some cases 0.5 M, th…
Article
Protein L affinity resin is ready to move to manufacturing
After comparing resin performance for mAb, Fab, and dAb samples, MabSelect™ VL protein L resin offered increased binding capacities versus other resins. This improvement could address existing protein…
Poster
Evaluation of Protein A resin lifetime during extensive use (overloading) in continuous chromatography mode
In recent years, continuous chromatography has emerged as an alternative to batch operations to improve productivity or increase resin capacity utilization of chromatography purification processes. …
Article
Sanitization Opportunities for Protein A Resins
Several protein-based chromatography resins are also sensitive to such harsh sanitization conditions. As an alternative, the oxidizing agent peracetic acid (PAA) could be used in the control of such c…
Article
Capto™ High Productivity Resins
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