Search results for " size exclusion"
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Process Chromatography Selection for Downstream Processing Applications
…ductivity, since the binding of impurities is primarily due to van der Waals interactions as well as size exclusion.
Membrane adsorbers have been available for more than a decade, and while their…
Article
Protein Characterization Using SEC: Three Webinar Takeaways
With more than thirty years in protein science, Åke Danielsson, Research Director at Cytiva, recently held a webinar on protein characterization using size exclusion chromatography (SEC). Here, …
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Single-Domain Antibodies for Brain Targeting
Single-domain antibodies are emerging as credible alternatives due to their target specificity, high affinity, and cost-effective recombinant production.
Smaller recombinant antibody fragments a…
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Ensure SEC Column Reproducibility in Protein Drug Analysis
Size exclusion chromatography (SEC) is the go-to analytical method in the analysis of therapeutic protein drugs. This article describes the factors affecting the reproducibility of columns and how you…
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Ensuring Viral Safety of Viral Vaccines and Vectors
Ensuring Viral Safety of Viral Vaccines and Vectors
Viral vaccines and viral vectors used in biotherapeutic applications carry the risk of microbial contamination, which must be addressed.
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Putting Viral Clearance Capabilities to the Test
“Virus retentive filtration is based on size exclusion, and a model of a specific size will represent all viruses of the same or greater size. But removal with chromatography steps is based on the vir…
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Impurity Testing of Biologic Drug Products
… structures
• Sedimentation velocity analytical ultracentrifugation (SV–AUC), size exclusion chromatography coupled to multi angle light scattering (SEC–MALS) or dynamic light scatterin…
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Column Tips for Successful SEC-MALS
Do you identify molecules using MALS, maybe in combination with size exclusion chromatography (SEC)? We have gathered Column Tips for Successful SEC-MALS in a blog post. Tap into these column …
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How to Optimize Protein Desalting
But how do you determine which method to use? And how do you choose the right product for your needs? Learn more in this blog post about using size exclusion chromatography (SEC) for this purpose.
Poster
Process economy effects of modernizations in vaccine purification
The vaccine industry is currently considering modernization of old, legacy processes. Old purification steps are being made obsolete by introducing modern purification techniques, aiming for increas…