Search results for " MabSelect"

Poster Packing MabSelect™ and MabSelect SuRe™ media using verified methods
This procedure describes packing of MabSelect and MabSelect SuRe media (resins) in large-scale chromatography columns including AxiChrom™, BPG, and Chromaflow™ columns. The procedures include ro…

Poster Impact of sporicidal agent on MabSelect SuRe™ protein A resin lifetime
In this application note, the effects of treating MabSelect SuRe protein A affinity  resin with 20 mM PAA every fourth process cycle for more than 100 cycles were investigated. The results show that t…

Article Current advances in Protein A chromatography
The MabSelect™ family of affinity chromatography media, which is based on the protein A ligand, has found wide acceptance among large-scale commercial manufacturers of biopharmaceutical MAbs. This med…

Article Re-use of Protein A Resin: Fouling and Economics
Some of the major Protein A resins that are commercially available include MabSelect (GE Healthcare), MabSelect Xtra (GE Healthcare), MabSelect SuRe (GE Healthcare), MabSelectSuRe LX (GE Healthcare), …

Article Process Economy Simulations on a Protein A Capture Step
This application note gives calculation examples that highlight scenarios where the enhanced capacity and alkaline‐stability of MabSelect PrismA can provide process economic benefits to large‐scal…

Article Capacity and Performance of a Next Generation Protein A Chromatography Resin
The resin exhibits improved capacity over its predecessor MabSelect SuRe™ products, while maintaining purification performance. This application note demonstrates the binding capacity and purification…

Article Faster scale-up of a two-step MAb process with AxiChrom™ columns and ReadyToProcess™ solutions
This process employed MabSelect SuRe™ and Capto™ adhere, which were packed automatically to bed heights of 20.5 cm and 14.1 cm, respectively. A DoE approach and Monte Carlo simulation were used to ver…

Article Achieving Greater Efficiency in the Production of Biosimilar Antibodies
Today, MabSelect SuRe™ LX reaches binding capacities of 60 g/L, while also providing caustic resistance to simplify cleaning-in-place operations and enhancing the lifetime of the resin. The additional…

Article High-throughput screening methods to speed MAb process development
…One study describes an optimized capture step for the purification of a monoclonal antibody (MAb) on MabSelect SuRe, which is a Protein A-based affinity chromatography medium. The use of PreDictor pr…

Poster Evaluation of Protein A resin lifetime during extensive use (overloading) in continuous chromatography mode
This application note compares the performance of MabSelect SuRe pcc resin designed for continuous capture of mAbs, with the conventional high-capacity Protein A resin MabSelect SuRe LX. The study was…

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