Search results for " modeling"

Article Mechanistic Modeling of Preparative Ion-Exchange Chromatography
For complex unit operations such as process chromatography, mechanistic modeling can assist in developing a systematic approach for process development, monitoring, and control. Models can also be jud…

Article Modeling Bioreactor Performance
Why model bioreactor performance? There are many reasons why biopharmaceutical manufacturers invest in the development of bioreactor modeling capabilities. Modeling is used to gain insight into no…

Article Leveraging Computational Models of Glycosylation for Biopharma QA
This review focuses on how different modeling strategies can be leveraged to aid in product QA across the different stages of biopharmaceutical product development and manufacture. Technical details o…

Article Modeling the Degradation of mAb Therapeutics
Kinetic modeling can be an effective tool for establishing product stability, offering a deeper understanding of these processes and allowing developers to mitigate the risk of product degradation dur…

Article Mechanistic Modeling: Does it Have a Future in Process Development?
…on, complexity, and lack of know-how on how to deploy are found too extensive when using mechanistic modeling. Novo Nordisk uses mechanistic models for the development of selected downstream process …

Article Modeling and Miniaturization: Key Topics at Successful HTPD Conference
Ottens reviewed how knowledge-based chromatographic process development based on mechanistic modeling will become more important and more utilized in the industry in the coming years. He also emphasiz…

Article Utilization of Mechanistic Modeling to Improve Process Development
Utilization of mechanistic modeling of unit operations, based on scientific and physical understanding of the process, is one of these approaches. Improved computational resources in the past decade h…

Article A DoE Q&A With GE Healthcare Part 3: Models and Evaluations
More from GE Healthcare’s recent webcast: Fundamentals of DoE in Protein Production and Purification During the live broadcast, many good questions from the audience were received. The limited…

Poster Process economy modeling for viral vector production
Viral vectors, such as adenovirus, adeno-associated virus, and herpes simplex virus, can be used in cancer therapeutics and in vaccines for chronic diseases and are thus expected to become high-valu…

Article Going Small to Achieve Success on the Commercial Scale
He adds that timing and planning of modeling runs is also important and can negatively influence results if not done effectively. For example, it is important to use the same feed used for production …

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