Search results for " modeling"

Article Modeling and Miniaturization: Key Topics at Successful HTPD Conference
Ottens reviewed how knowledge-based chromatographic process development based on mechanistic modeling will become more important and more utilized in the industry in the coming years. He also emphasiz…

Article Rethinking ion exchange chromatography modeling
In the early days of modeling, mechanistic models for ion exchange chromatography were mostly based on stoichiometric equations. A new adsorption isotherm class was introduced in 2021: the co…

Article FAQ: Scale-up and scale-down with mechanistic modeling
…e the correct scale for model calibration, and understand how scale-up integrates into a mechanistic modeling workflow. READ FULL FAQ ARTICLE >>

Article Utilization of Mechanistic Modeling to Improve Process Development
Utilization of mechanistic modeling of unit operations, based on scientific and physical understanding of the process, is one of these approaches. Improved computational resources in the past decade h…

Article Adsorption isotherm models for chromatography
Read on commonly used models for the thermodynamics of adsorption within a chromatography column. Indeed, in order to create a complete chromatography model, the adsorption of compon…

Article Advanced therapeutics process development using mechanistic modeling
what the challenges are in process development when working with both diverse molecules and mechanistic modeling. MORE Q&As WITH INDUSTRY LEADERS >>

Article Mechanistic vs Statistical Models
Mathematical models are recommended by the ICH Q8 guidelines on pharmaceutical development to generate enhanced process understanding and meet Quality-by-Design (QbD) guidelines. Read on the d…

Article Developing a Robust Bioprocess Using Mechanistic Models
The safety and efficacy of a biopharmaceutical drug are of the highest priority. Therefore, manufacturers have to design, implement and maintain measures to ensure that the bioprocess con…

Article Do Modeling and Simulation Tools Really Benefit the Biosimilar Industry?
The business impact of modeling and simulation tools is not well understood and requires clarification of their benefits to drug development. READ THE FULL ARTICLE >>…

Article Engage a mechanistic modeling expert – or become one
The application of mechanistic modeling requires expertise for effective use. When planning to implement this ground-breaking technology one essential question must be addressed befor…

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