Search results for " cell culture"

Article Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
Cells used for biopharmaceutical applications are mainly of animal origin and can be cultured in suspension or adherent cell cultures. A unique characteristic of adherent cells is their dependence on …

Article A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
…dose (FHD) or first-in-human (FIH) application, and leveraging a “commercializable” platform for cell culture and downstream process development. At the heart of this strategy is the view that the pr…

Article Scale-up of adherent Vero cells grown on Cytodex microcarrierrs using ReadyToProcess equipment
Introduction Compared to an egg-based vaccine production, cell culture based vaccine production is seen as an alternative way for a more rapid response to pandemic challenges. Traditionally, cel…

Article Changing the Culture of Cell Culture: Applying Best Practices and Authentication to Ensure Scientific Reproducibility
Microbial contamination of continuous cell cultures by a wide variety of microorganisms is also problematic in cell culture laboratories worldwide, particularly by mycoplasma. The latter can be diffic…

Article The Evolving Role of Starting Materials in Cell and Gene Therapy
The Evolving Role of Starting Materials in Cell and Gene Therapy Accelerated approval pathways and growing demand for cell and gene therapies are putting pressure on providers of cellular starting m…

Article Best Practices for Selecting a Top-Quality Cell Line
Irina Shi - Stock.Adobe.com Leveraging automation and a step-by-step approach are keys to success. By Cynthia A. Challener Cell lines determine the performance of bi…

Article Mapping a Route for Cell and Gene Therapy Process Development
Looking at cell therapies, Baghbaderani notes that the main differences in scaling allogeneic applications lies in the cellular characteristics, cell culture systems, and unit operations utilized in t…

Article Design Considerations for a Commercial Cell and Gene Therapy Facility
“The scales of processing at the moment top out at about 2000 L of cell culture, which is in line with smaller mAb manufacturing processes,” Ramaswamy states. On the other hand, cell and ex-vivo…

Article Challenges in Cell Harvesting Prompt Enhancements
Challenges in Cell Harvesting Prompt Enhancements Higher cell titers and cell densities have posed a challenge to cell harvesting, a crucial step in biologics manufacturing. By Feliza Mi…

Article Large-scale cell culture using Cellbag™ bioreactors with embedded optical sensors
Disposable bioreactor for cell culture using wave-induced agitation. Cytotechnology 30, 149-158 (1999). 2. Namdev, P.K. and Lio, P. Assessing a disposable bioreactor for attachment dependent cel…

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