Search results for " cell culture"

Article Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
Cells used for biopharmaceutical applications are mainly of animal origin and can be cultured in suspension or adherent cell cultures. A unique characteristic of adherent cells is their dependence on …

Article A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
…dose (FHD) or first-in-human (FIH) application, and leveraging a “commercializable” platform for cell culture and downstream process development. At the heart of this strategy is the view that the pr…

Article Scale-up of adherent Vero cells grown on Cytodex microcarrierrs using ReadyToProcess equipment
Introduction Compared to an egg-based vaccine production, cell culture based vaccine production is seen as an alternative way for a more rapid response to pandemic challenges. Traditionally, cel…

Article Changing the Culture of Cell Culture: Applying Best Practices and Authentication to Ensure Scientific Reproducibility
Microbial contamination of continuous cell cultures by a wide variety of microorganisms is also problematic in cell culture laboratories worldwide, particularly by mycoplasma. The latter can be diffic…

Article Challenges in Cell Harvesting Prompt Enhancements
Challenges in Cell Harvesting Prompt Enhancements Higher cell titers and cell densities have posed a challenge to cell harvesting, a crucial step in biologics manufacturing. By Feliza Mi…

Article Large-scale cell culture using Cellbag™ bioreactors with embedded optical sensors
Disposable bioreactor for cell culture using wave-induced agitation. Cytotechnology 30, 149-158 (1999). 2. Namdev, P.K. and Lio, P. Assessing a disposable bioreactor for attachment dependent cel…

Article Trends in Fermentation and Cell Culture Equipment
The discussion focused on future trends in fermentation and cell culture equipment. Parrish Galliher began his career in 1981 at Biogen, where he was responsible for the design, commissi…

Article Implications of Cell Culture Conditions on Protein Glycosylation
In mammalian cell culture processes, the use of different species can potentially produce significant differences in the types of glycosylation that can occur. These differences in glycosylation can h…

Poster Benchmarking, scalability, and protein production in CHO cell culture
With the large number  of CHO clones in use, it is important to have a cell culture medium that supports high viable cell counts and  productivity with multiple cell clones. A precise balance of nutri…

Poster A streamlined single-use solution for an intensified high-density cell culture process
However, for successful implementation of intensified cell cultures, challenges such as increased hardware and operational complexity need to be overcome. With advantages such as ease of imple…

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