Search results for " optimization"
Article
Combining Microbioreactors and Advanced Statistical Techniques to Optimize a Platform Process for a New Host-Cell Line
This has enabled design of experiment (DoE) approaches, such as response surface optimization, to be used. Second, better systems for collecting, storing, and analyzing process data have facilitated t…
Article
Robust Optimization, Simulation, and Effective Design Space
Little, PhD
BioPharm International
Volume 28, Issue 7, pg 40–44
Approaches to the generation of process models, optimization techniques, and application of a design space are explored.
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Article
Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
This step often requires more optimization than initial capture and/or final polishing and aims to achieve high-dynamic binding capacity and maximum aggregate and host-cell protein (HCP) clearance. In…
Article
Optimization of Protein Expression in Escherichia Coli
The refolding step adds an additional stage in the purification process, however, and requires additional time for optimization. This increases the cost of production. In addition, only a fraction of …
Article
Optimizing your Cell Culture Process to Improve Productivity
You can use it to characterize subculture system parameters for process optimizations. Optimal ranges can be determined for various components, and this allows you to keep your cells healthy and produ…
Poster
Strategies for optimized cell culture media: Effectively using design space to influence product quality
Further rounds target optimization of factor levels. The following case study presents a two-part screening campaign that was used to target charge variant factors. Results indicate that several condi…
Article
Optimizing Late-Stage and Commercial Cell-Culture Processes
Optimizing Late-Stage and Commercial Cell-Culture Processes
Late-stage and commercial biomanufacturing pose a challenge to cell-culture processing.
By Feliza Mirasol
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Article
Process Chromatography: Continuous Optimization
Improved resin chemistries and customized separation solutions are enabling more efficient separations.
By Cynthia A. Challener
Cell-culture and fermentation are high-…
Article
Maximum Output Starts with Optimized Upstream Processing
On a positive note, parallelization of experiments using automated systems for high-producer clone selection, along with medium optimization and the availability of standard kits, are having an overwh…
Article
Determining and Optimizing Dynamic Binding Capacity
Determination and optimization of this value facilitates the development of efficient and productive chromatography operations. While the same general method is used to determine the DBC for many diff…