Search results for " optimization"

Article Combining Microbioreactors and Advanced Statistical Techniques to Optimize a Platform Process for a New Host-Cell Line
This has enabled design of experiment (DoE) approaches, such as response surface optimization, to be used. Second, better systems for collecting, storing, and analyzing process data have facilitated t…

Article Robust Optimization, Simulation, and Effective Design Space
Little, PhD BioPharm International Volume 28, Issue 7, pg 40–44 Approaches to the generation of process models, optimization techniques, and application of a design space are explored. …

Article Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
This step often requires more optimization than initial capture and/or final polishing and aims to achieve high-dynamic binding capacity and maximum aggregate and host-cell protein (HCP) clearance. In…

Article Optimization of Protein Expression in Escherichia Coli
The refolding step adds an additional stage in the purification process, however, and requires additional time for optimization. This increases the cost of production. In addition, only a fraction of …

Poster Strategies for optimized cell culture media: Effectively using design space to influence product quality
Media optimization requires incorporation of progressive statistical strategies. First, a screening model is used to identify the key components that influence critical culture attributes (e.g., titer…

Article Optimizing Late-Stage and Commercial Cell-Culture Processes
Optimizing Late-Stage and Commercial Cell-Culture Processes Late-stage and commercial biomanufacturing pose a challenge to cell-culture processing. By Feliza Mirasol …

Article Process Chromatography: Continuous Optimization
Improved resin chemistries and customized separation solutions are enabling more efficient separations. By Cynthia A. Challener Cell-culture and fermentation are high-…

Article Optimization of Fed‑Batch Culture Conditions for a mAb‑Producing CHO Cell Line
This application note describes a broadly applicable and efficient workflow toward finding the optimal feed combination for the best-performing fed-batch processes.  An IgG1-producing CHO cell l…

Article HTPD Webinar: Optimizing a mAb Chromatography Polishing Step
Development of robust purification processes requires significant time and resources. In addition, steadily increasing demands from regulatory authorities for better understanding and control of man…

Poster Optimal configuration of ÄKTA™ pure 25 for small-scale SEC
When running small-scale size exclusion chromatography (SEC) it is important to keep the internal volume in the chromatography system as low as possible for optimal performance. Tubing and component…

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