Search results for " anion exchange"

Article Application of Quality by Design to Viral Safety
…design spaces for two unit operations commonly used in monoclonal antibody production, Protein A and anion exchange chromatography (12, 13). For Protein A chromatography, Genentech found no meaningfu…

Article Enhancing Resins Addresses Purification Concerns
Deorkar notes that hydrophobic interaction chromatography (HIC) and anion exchange (AEX) chromatography can be used, but careful optimization of conditions is required to be applicable for large-scale…

Article The Challenge of Disruptive Technologies in Bioprocessing
Next-generation ion exchange chromatography resins like POROS XS (strong cation exchange) and XQ (strong anion exchange) offer high capacity, high resolution, and salt tolerance at faster flow rates f…

Article Impurity Testing of Biologic Drug Products
… MS), LC–MS, and other liquid chromatography with ultraviolet detection (LC–UV) or high-pressure anion exchange chromatography coupled to pulsed amperometric detection (HPAEC-PAD) methods for the qua…

Article Modeling and Miniaturization: Key Topics at Successful HTPD Conference
Integration of parallel micromixers and microcolumns (50-70 nL scale) on the chip allowed solid-phase micro-column anion exchange linear gradient chromatography on a single chip. Smart Process Dev…

Article A Look at the Affinity Chromatography Landscape
A Look at the Affinity Chromatography Landscape New ligands are being developed to meet the separation and purification needs of next-gen biologics. By Cynthia A. Challener …

Poster Fast Trak Services: a collaborative project to accelerate downstream biosimilar process development
…ntermediate purification and polishing steps, using hydrophobic interaction chromatography (HIC) and anion exchange chromatography (AIEX), respectively, keeping the same process materials. In additio…

Article Viral Clearance Challenges in Bioprocessing
…ve inactivation or removal could be demonstrated under standard conditions like low pH inactivation, anion exchange (AEX) chromatography, or virus-retentive filtration? Further studies need to be per…

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