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Article Insights and Strategies for Successful Development of Scalable AAV Processes: Part 2 of 2
Topics covered include: 1:00 – The upstream approach for AAV production, such as finding the balance between different parameters in the design of experiments to create a robust production proc…

Article Top Challenges to Overcome When Developing AAV Processes: Part 1 of 2
Topics covered include: 1:00 – Two main challenges for upstream AAV process development, including which development platform to use and scalability 3:09 – Parameters evaluated for AAV p…

Article How to optimize AAV capsid separation
In this free, interactive course you’ll learn how to tackle one of the key challenges in Adeno-associated virus (AAV) manufacturing–separating full and empty capsids in the polishing step. You’ll …

Article A deep dive into optimizing AAV capture and polishing to maximize both yield and purity
To meet these needs, Cytiva developed scalable capture and polishing chromatography steps for recombinant AAV (rAAV). The affinity capture step maximizes recovery and efficiently removes impurities. …

Article Scalable AAV Production Process for Gene Therapy
Several viruses have been investigated for use in cell and gene therapy; adeno-associated virus (AAV) has emerged as the main vector for gene therapies. Here, we describe how we developed an efficient…

Article Balancing AAVs Versus LLVs
Balancing AAVs Versus LLVs

Article Cell culture process development for AAV vector production in suspension cells
Adaptation of HEK293 suspension cell line for transient transfection and scalable adeno-associated virus (AAV) production. READ FULL ARTICLE >>

Article The GMP of AAV: Purification for Clinical Production
Watch this presentation to learn about the key considerations when developing a purification process for adeno-associated viruses (AAV).  >>> Learn more

Article Successful Development of Scalable AAV Processes: Part 2 of 2
Watch the Q&A interview >> In the second of a two-part series, Anki Magnusson, Staff Research Engineer, Protein and Viral Production, and Åsa Hagner-McWhirter, PhD, Senior Scientist, Bio…

Article Top Challenges to Overcome When Developing AAV Processes: Part 1 of 2
Watch the Q&A interview >> In the first of a two-part series, Anki Magnusson, Staff Research Engineer, Protein and Viral Production, and Åsa Hagner-McWhirter, PhD, Senior Scientist…

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