Search results for "adenovirus"

Article Developing an Efficient Adenovirus Downstream Purification Process
Adenovirus is also explored as a potential viral vector for gene therapy and as an oncolytic virus. This application note describes the development of downstream chromatography steps for purification …

Article Achieving Efficient Adenovirus Upstream Production
Adenovirus has also been explored as a viral vector for gene therapy and as an oncolytic virus. This application note describes the production of adenovirus in HEK293 suspension cells in a bioreactor …

Article Case Study: Process for Production of Oncolytic Adenovirus
Here, we present a case study from a biomanufacturer developing a process for adenovirus oncolytic adenovirus production. The case study describes a process from upstream cell culture to downstream pu…

Article Optimization of Adenovirus Midstream Purification Steps
In this application note, studies of midstream purification steps in an adenovirus production process is performed. Based on the results, suggestions for the choice of consumables and conditions for v…

Article Evaluation of HEK293 Cell Growth and Adenovirus Productivity in HyClone™ CDM4HEK293 Medium
HEK293 cells are susceptible to infection by adenovirus, one of the most frequently used viral vectors in the development of therapeutic vaccines and vaccines against infectious diseases. This applica…

Poster Adenovirus production in a single-use stirring tank bioreactor system
In this work we demonstrate an efficient process for adenovirus production in a single-use stirred-tank bioreactor, using HEK293 cells adapted for suspension culture. Human adenovirus 5 expressing gre…

Poster A Scalable Adenovirus Production Process, from Cell Culture to Purified Bulk
Adenovirus (AdV) vectors are commonly used in cancer gene therapy trials and evaluated for use in vaccines for various diseases. In this study, we have combined technical evaluation of process steps a…

Poster A Scalable Adenovirus Production Process
To meet these needs, a process for adenovirus production, from upstream cell culture to downstream purification, using modern tools and technologies was developed. The novel process is easily sc…

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Article Process Economic Simulation for Scalable Production of Adenovirus
This application note discloses the process economic modelling of a modern start-to-finish adenovirus production process. The novel process was compared with a reference process in both stainless-st…

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