Search results for " purity"

Article Improving Process-Scale Chromatography
“Affinity resins are a powerful tool for capture chromatography due to the high degree of purity obtained after a single processing step,” Lynch states. Ljungqvist adds that for antibody fragments…

Article Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
Downstream Processing and Purity Analysis For downstream laboratory-scale purification, performed using standard, non-disposable equipment, approximately 10 L virus harvest from the upstream proce…

Article Top challenges in recombinant protein purification process development
The number one challenge they face is that they're unable to get good purity in their first step. If they could use an affinity solution, they could get more than 95% purity already in the first step.…

Article Enhancing Resins Addresses Purification Concerns
Each [protocol] needs to achieve high-yielding purification protocols to bring vaccines to the market in short time and in high purity,” Ihre explains. “For some, but not all modalities, platform proc…

Article Driving Improved Access to Biosimilars
… it is easy for different manufacturers to produce virtually the same product and to achieve product purity levels of 99% or higher, she says. But she notes that is not always true for biopharmaceuti…

Article Combining Purification Techniques in a Multistep Approach
…proach, your protein purification will be successful in terms of either high target protein yield or purity. In this blog post, learn how to select and combine purification techniques to successf…

Poster Fast Trak Services: a collaborative project to accelerate downstream biosimilar process development
Consequently, low product recovery and purity were obtained in  the first-generation purification process. In addition, the purification protocols were poorly suited for  manufacturing scale. …

Article Evaluation of Fibro PrismA for Scalable Single-Use mAb Purification
The team assessed scalability from lab- to process-scale units, tracking pressure drop, step recovery, purity, and eluate volumes across multiple cycles.

Article Genetic Vaccine Platforms Demonstrate Their Potential
“Full focus on SISPQ (safety, identity, strength, purity, and potency) is common to all medicines. However, for genetic vaccines, this means developing a whole new battery of analytical methods, espec…

Article The Evolving Role of Starting Materials in Cell and Gene Therapy
Because contaminating cell types can slow or complicate downstream isolation protocols, yield and purity should be balanced with the goal of consistently delivering maximum therapeutic efficacy to the…

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