Search results for " perfusion"
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Trends in Single-use Bioreactors
Galliher (Cytiva): The latest innovations include higher-power microbial bioreactors, as well as improved capabilities for continuous perfusion. Single-use stirred-tank fermentation technology has bee…
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Continuous Processing for the Production of Biopharmaceuticals
Technology enablers for continuous manufacturing
While the biotech industry has extensive experience in continuous upstream processing, commonly called perfusion, there has also been extensive dev…
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Maximum Output Starts with Optimized Upstream Processing
The use of perfusion processes has enabled even larger throughputs within the same bioreactor volume.
Furthermore, Chilima observes that by using scalable technologies that have representative sca…
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State of the Biopharmaceutical Industry: Lessons from 2018 Survey Data
When asked about significant concerns with continuous perfusion versus upstream fed-batch operations, over two-thirds of respondents (68.9%) cited "Process development control challenges" with perfusi…
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Hybrid Bioprocessing: A Q&A with Andrew Sinclair
In the upstream arena, people often refer to perfusion as a variant of continuous. This is a mature technology and the economics are well understood. Where the productivity of the cell line is equival…
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Single-Use Technologies Prove Effective for Viral Vector Process Development
Finally, Ram points out that the use of perfusion in fixed-bed bioreactors is simpler than in traditional stirred tanks because the attachment matrix essentially acts as the cell retention device, whi…
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Developing a Continuous Large-Scale Prefusion Cell Culture Process
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Perfusion processes enable continuous operation over extended periods of time by constantly providing fresh nutrients for the cells and simultaneously removing …
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Scaling Up Novel Therapies
One way they do this, he says, is by “scaling out,” intensifying processes, for example by using fed-batch and perfusion on the upstream side, and multicolumn operations, whether it’s just higher cycl…
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Integrated Semi-Continuous Process for mAb Production
Linking these different steps together to a fully continuous process can be a challenging task, and studies in the area of continuous processes typically deals with single unit operations, such as per…
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Bioprocessing Advances in Vaccine Manufacture
This includes perfusion. Capillary hollow-fiber perfusion bioreactors being developed by FiberCell Systems, for example, are expected to comparably produce up to 1000 x (based on bioreactor size) the …