Search results for "mRNA"
mRNA Therapeutics and Vaccines – Key Process Considerations
Click here >> Learn more on key considerations and strategies for process development and scaling up in our new web hub for mRNA therapeutics and vaccines.
Genetic Vaccine Platforms Demonstrate Their Potential
Genetic vaccines include messenger RNA (mRNA)/DNA. Alternatively, vaccines can be classified into live and non-live vaccines, which is important when considering safety profiles. Traditional v…
Can Vaccine Development Be Safely Accelerated?
Prophylactic messenger RNA vaccines Two companies, both also supported by grants from CEPI, have developed platform technologies based on messenger RNA (mRNA). Cambridge, MA-based Moderna—which ha…
A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
Evaluation of integrity of the transgene mRNA expressed in CHO cells RNA splicing is a natural process in mammalian cells that removes introns and joins exons in a primary transcript to create matu…
Techniques for Improving Process Development for Exosome-Derived Therapeutics
One cancer treatment with enormous potential is for exosomes to deliver siRNA and knock down the expression of oncogenic mRNA. The laboratory of Dr. Raghu Kalluri, one of our founders at The Universit…
Strategizing for Rapid Changeovers in Biologics Manufacturing
The same goes for the mRNA platform, where processes are similar between different candidates. By using multiple platforms, the risk for failure can be mitigated,” he explains. In addition, given …
Gene Therapies Push Viral Vector Production
That being said, other technologies such mRNAs delivered to the target cells with, for example, mammalian cell-line produced engineered exosomes, start to show their capabilities,” Touw interjects. “A…
Emerging Therapies Test Existing Bioanalytical Methods
It is also used to measure the expression levels of transgene- expressed mRNA in target tissue for gene therapy programs. PCR is a widely used platform; however, there is a lack of specific regulatory…
Platform Technologies Improve Protein Expression
A cytomegalovirus (CMV) promoter drives the transcription of one mRNA from which two proteins are translated (i.e., the protein of interest [product] and a functionally impaired Zeocin selection marke…
Patenting Prospects for Cell-Based Therapies
Myriad Genetics (“Myriad”) (8), in which the Court deemed patent ineligible DNA isolated from nature (while at the same time deciding that cDNA, made from mRNA converted by the viral enzyme reverse tr…