Search results for "hcp"

Article Manage HCPs and Enhance Your Route to Market
Learn how the right HCP strategy can enhance your route to market.

Article Why, why, why…ELISA? A Look at the Benchmark HCP Assay
Biologics developers and manufacturers demand an accurate and reliable assay for host cell protein (HCP) quantitation. Let’s take a close look at why analytical scientists turn to the ELISA and how it…

Article News: GE Healthcare Adds ELISA Kit to End-to-End HCP Monitoring Capabilities
GE Healthcare Life Sciences is pleased to announce the new Amersham HCPQuant CHO kit, a generic for detecting host cell protein impurities in drug samples produced in CHO cell lines. Learn Mor…

Article Host-Cell Protein Measurement and Control
The amount of residual HCPs in drug product is generally considered a critical quality attribute (CQA), due to their potential to affect product safety and efficacy. Therefore, it is a regulatory requ…

Article Managing Residual Impurities During Downstream Processing
… the natural, simultaneous production of other unwanted materials, particularly host-cell proteins (HCPs). Host-cell DNA will also be present and must be minimized by the purification process. Elemen…

Article Polishing of monoclonal antibodies using Capto adhere ImpRes in bind and elute mode
The results showed high yields of monomeric MAb, as well as good clearance of aggregates, host cell proteins (HCP), and leached protein A.    Introduction MAbs and MAb conjugates are today …

Resource Challenges of Host Cell Protein Analysis with ELISA and How to Obtain Better Coverage of Your ELISA
Due to its complex composition and low abundance levels in the final product, sandwich ELISA is often used as the workhorse for HCP testing for its high sensitivity and high throughput. However, the d…

Article Polishing of Monoclonal Antibodies using Capto™ MMC ImpRes in Bind and Elute Mode
The results show high yield of monomeric MAb, as well as good clearance of aggregates, host cell proteins (HCP), and leached protein A.   Download the app note here or continue reading, below. …

Article Eliminating Residual Impurities Starts with a Strategic Plan
Others are more complex to define, such as those that originate from the cellular system including residual DNA or host-cell proteins (HCPs),” Wake observes. “In the latter case, for instance, conside…

Article Development of Purification for Challenging Fc-Fusion Proteins
As tested on three Fc-fusion proteins, this process demonstrates high process yield, improved clearance of HMWs and LMWs, and efficient reduction of host cell proteins (HCP) and DNA as well as robust …

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