Search results for " Protein A resin"

Article Re-use of Protein A Resin: Fouling and Economics
The most significant contributor to the total cost is the Protein A resin. The cost of Protein A resin is nearly 50% higher than traditional chromatographic media with nonproteinaceous ligands (2, 10)…

Article Development of Purification for Challenging Fc-Fusion Proteins
Development of Purification for Challenging Fc-Fusion Proteins This study outlines methods for an alternative protein-polishing process for challenging proteins. …

Article Comparing Protein A Resins for Monoclonal Antibody Purification
A team from Chugai Pharmaceutical (Japan) investigated the mAb purification performance of a new alkali-tolerant, prototype Protein A resin (Resin 3, MabSelect SuRe LX prototype, GE Healthcare), which…

Article Development and Future of Protein A Chromatography Technology: Q&A with Jonathan Royce, Business Leader Chromatography Resins, GE Healthcare
Although Protein A resins introduced to the market in the last 10 years withstand low to medium concentrations of sodium hydroxide for cleaning, like 0.1 M sodium hydroxide and in some cases 0.5 M, th…

Article Improvements in Protein A Chromatography
However since 1978, the capacity and productivity of Protein A resins have improved at a rate of about 5% a year. The net effect of this improvement is that newer resins are an order of magnitude bett…

Article Challenges of Protein Aggregation During Purification
Careful selection of downstream processing conditions is a must. Sep 1, 2014 By: Cynthia Challener, PhD BioPharm International Volume 27, Issue 9, pp. 32-35  Removal of protein a…

Article Capture of human single-chain Fv (scFv) fusion protein on Capto L affinity medium
We describe the capture of a single-chain Fv fusion proteinfrom a challenging feedstock (animal plasma) on the affinitychromatography medium (resin) Capto™ L. Initial work on smallprepacked HiScreen™ …

Article Cleaning Protein A Resins with 1 M NaOH
If not removed, these impurities can build up on the protein A resin and start to leach into the process material in subsequent cycles. The presence of cell culture nutrients in the harvest feed loade…

Article Capacity and Performance of a Next Generation Protein A Chromatography Resin
Click here to read application note: Capacity and performance of MabSelect™ PrismA protein A chromatography resin For more information, visit MabSelect Protein A resins

Poster Evaluation of Protein A resin lifetime during extensive use (overloading) in continuous chromatography mode
This application note compares the performance of MabSelect SuRe pcc resin designed for continuous capture of mAbs, with the conventional high-capacity Protein A resin MabSelect SuRe LX. The study was…

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