Search results for " antibody production" in Articles / App Notes
Article
Witnessing Major Growth in Next-Generation Antibodies
Including next-gen antibodies in pharma pipelines is considered essential for future success.
By Cynthia A. Challener
Next-generation antibodies are designed to be more specific and are ofte…
Article
Antibody Production in Microbial Hosts
Motivation for antibody production in microbial hosts
Mammalian cells have been predominantly employed for the expression of antibodies and related products because of their ability to introdu…
Article
Defining Critical Quality Attributes for Monoclonal Antibody Therapeutic Products
An approach for establishing the CQAs of a mAb product by evaluating impact and uncertainty during risk assessment.
A critical quality attribute (CQA) has been defined as “a physical, chemical, …
Article
Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
Surface plasmon resonance is helping define bispecific antibodies, the next-generation of biopharma therapeutics.
By Robert Karlsson
Abstract
Biotherapeutic antibodies are still the larg…
Article
Generating a Fully Processed Antibody
This was important for this study to obtain enough FGE production in the context of high antibody production.
Development and selection of high-expressing FGE clonal cell line
Figur…
Article
Impact of Media Components on CQAs of Monoclonal Antibodies
Pluronic F-68 and Putrescine showed positive effect on cell growth and antibody production (2). Carboxymethyl cellulose and polyvinyl pyrrolidone are used as protective agents. Dimethyl sulfoxide (DMS…
Article
Single-Domain Antibodies for Brain Targeting
Single-domain antibodies are emerging as credible alternatives due to their target specificity, high affinity, and cost-effective recombinant production.
Smaller recombinant antibody fragments a…
Article
HT Multi-Product Liquid Chromatography for Characterization of Monoclonal Antibodies
If used correctly, these new analytical methods can reduce analysis and product development time.
ABSTRACT
Monoclonal antibodies represent a significant portion of sales in the biopharma…
Article
The Development and Application of a Monoclonal Antibody Purification Platform
A purification scheme to maximize the efficiency of the purification process and product purity while minimizing the development time for early-phase therapeutic antibodies.
The following ar…
Article
Concentrating Feed—an Applicable Approach to Improve Antibody Production
Although higher concentrations of feed media could be obtained by raising pH, there was an optimal pH of feed media in which cell growth and antibody production were not adversely affected. The additi…