Search results for "antibody fragments"

Article Witnessing Major Growth in Next-Generation Antibodies
The global market for next-generation antibodies, including antibody drug conjugates (ADCs), engineered antibodies, bispecific antibodies, antibody fragments, antibody-like proteins and biosimilar ant…

Article Antibody Production in Microbial Hosts
Therapeutic mAbs and their derivatives—such as antibody fragments (Fab), single-chain Fv (scFv), and diabodies—represent the fastest-growing class of approved therapeutic proteins because of their hig…

Article Single-Domain Antibodies for Brain Targeting
Smaller recombinant antibody fragments as single-domain antibodies (sdAbs) are emerging as credible alternatives because of their target specificity, high affinity, and cost-effective recombinant prod…

Article Advances in Linker Technology: Improving the Safety and Efficacy of Antibody Drug Conjugates
The Fleximer linker can also be used with antibody fragments, which are easier to manufacture and may achieve better and deeper cell penetration than whole antibodies. “Because of the smaller protein …

Article A platform approach for the purification of antibody fragments (Fabs)
This platform approach enables increased efficiency and productivity in developing therapeutics based on antibody fragments. For a download of the complete app, click here .  For related …

Article Antibody Fragments and Their Purification by Protein L Affinity Chromatography
A majority of such molecules are monoclonal antibodies; however, many new entities are antibody fragments. Due to their structural, physiological, and pharmacological properties, antibody fragments of…

Article Evolution of the Monoclonal Antibody Purification Platform
The authors discuss the evolution of the purification platform for manufacturing of mAb therapeutics. Monoclonal antibodies (mAb) increasingly form the majority share of the product pipeline…

Article Defining Critical Quality Attributes for Monoclonal Antibody Therapeutic Products
An approach for establishing the CQAs of a mAb product by evaluating impact and uncertainty during risk assessment. A critical quality attribute (CQA) has been defined as “a physical, chemical, …

Article A Platform Approach to Purification of Antibody Fragments
Here, we present affinity chromatography resins that offer the possibility of a platform approach to the purification of the majority of antibody fragments. The described BioProcess™ resins offer high…

Article Resolving a bottleneck in screening and characterization of recombinant antibody fragments using Biacore 4000
These experiments demonstrate a new dimension for better-informed, more efficient selection of antibody fragments. Download application note.

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