Search results for " dAb"

Poster Scale-up and process economy calculations of a dAb purification process using ready-to-use products
A three-step dAb purification process was used as model. The results show that although operating expenses can be more extensive when scale and number of batches increase, ready-to-use equipment and r…

Article E. coli growth and Dab expression in single-use and stainless steel fermentors
Cell growth, cell density, and Dab expression levels were assessed and compared between the two production vessels. The  results show that the performance of the XDR-50 MO fermentor is comparable …

Article A Platform Approach for the Purification of Domain Antibodies (Dabs)
This platform approach, based on a capture step with Capto L, enables increased efficiency and productivity in developing therapeutics based on Dabs. Click here to download the application not…

Article Testa Challenge 2020 Attracts Leading International Bioprocessing Innovators
The 2020 challenge required entrants to show how their product or service would improve a real-life start to finish bioprocess run in the Testa facility by producing and purifying a dAb domain antibod…

Article High-Throughput Process Development in an Historical Environment
The challenge was to use HTPD workflows for maximized Dab purity and yield. A workshop held by Ashley Hesslein from Bayer HealthCare kicked off the meeting. The topic was “Lessons Learned in Build…

Article Antibody Production in Microbial Hosts
Figure 1: Structure of an antibody and its fragments: A) Antibody (IgG class); B) antibody fragments (VH, scFv, Fab, scFab, dAb, scFv-CH3). Abbreviations are: variable heavy chain (VH), variable light…

Article Get to know: mAb variants - eLearning
The diversity of antibody variants in the biotherapeutics pipeline are increasing with a growing interest for molecules like antibody fragments and bispecific antibodies (bsAbs). Cytiva has p…

Article Single-Use Workflow for Recovery of a Domain Antibody from E. coli Culture Feed in an Automated Manner
The dAb-containing sample was clarified (2.5-times concentration) and further washed with three wash volumes, with a recovery of approximately 90% of product in the permeate. Click here to view…

Article Process Chromatography Selection for Downstream Processing Applications
Industry experts discuss best practices for selecting a separation technology. By Caroline Hroncich Process chromatography has changed significantly since it was first introduced to the biop…

Poster Process economy and production capacity using single-use versus stainless steel fermentation equipment
coli Dab process. Production scenarios in both single- and multi-product facilities were considered. In comparison with a stainless steel strategy, this study shows that the annual production capacity…

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