Search results for " HTS"

Article Addressing the Challenges in Downstream Processing Today and Tomorrow
The HTS method has also been applied to the development of other purification processes for unique biotherapeutic modalities where screening of a large number of resins may be required. Another cons…

Poster Utilization of high-throughput screening in the development of HyCell™ CHO medium
The nutritional requirements of the Chinese hamster ovary (CHO) cell line vary specific to the individual recombinant clones isolated, often necessitating the development of a clone-specific product…

Article DoE Provides Benefits, but Preparation Is Necessary
Even with the use of HTS, however, implementation of DoE for formulation development can be time consuming and resource intensive and can translate into more extensive experimentation than planned, ac…

Article Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars A major advantage of SPR-based analysis is its ability to estimate the association and dissociation rate constants, an …

Article Miniaturization to Become Even More Successful
Industrial bioprocess development has changed significantly in the last decade, driven primarily by two major factors: ever-rising R&D costs of developing therapeutic candidates with simultaneous de…

Article Program Now Available for HTPD Conference
The preliminary program is now available for the 4th International High Throughput Process Development (HTPD) conference. This year, the HTPD conference will have an expanded scope covering process …

Article High-Throughput Process Development in an Historical Environment
As an example of their utilization, Chris Daniels from Merck presented work with design and commissioning of a BSL-2 HTS platform for process development of viral vaccine production, where all liquid …

Article Achieving Greater Efficiency in the Production of Biosimilar Antibodies
The biosimilars market is set to reach more than US$20 billion in 2020 and both established biopharma and younger therapeutic manufacturers will play their part in meeting demand. Despite growing re…

Article High-throughput screening and process development for capture of recombinant pro-insulin from E. coli
This application note describes a complete process-development workflow, from PreDictor™ plate screening to a 400 mL pilot-scale purification for capturing recombinant pro-insulin expressed in E. co…

Article High-throughput screening of HIC media in PreDictor™ plates for capturing recombinant Green Fluorescent Protein from E. coli
Hydrophobic interaction chromatography (HIC) is a powerful purification technique where the type and density of the ligand, pH and salt of binding conditions, temperature and the nature of the targe…

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