Search results for " adenovirus" in Articles / App Notes
Article
Developing an Efficient Adenovirus Downstream Purification Process
This application note describes the development of downstream chromatography steps for purification of adenovirus from HEK293 cell culture harvest.
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Article
Achieving Efficient Adenovirus Upstream Production
This application note describes the production of adenovirus in HEK293 suspension cells in a bioreactor system. Triplicate cultures demonstrate a reproducible and robust batch production of adenovirus…
Article
Case Study: Process for Production of Oncolytic Adenovirus
Here, we present a case study from a biomanufacturer developing a process for adenovirus oncolytic adenovirus production. The case study describes a process from upstream cell culture to downstream pu…
Article
Optimization of Adenovirus Midstream Purification Steps
In this application note, studies of midstream purification steps in an adenovirus production process is performed. Based on the results, suggestions for the choice of consumables and conditions for v…
Article
Evaluation of HEK293 Cell Growth and Adenovirus Productivity in HyClone™ CDM4HEK293 Medium
HEK293 cells are susceptible to infection by adenovirus, one of the most frequently used viral vectors in the development of therapeutic vaccines and vaccines against infectious diseases. This applica…
Article
Evaluation of Hek293 Cell Growth and Adenovirus Productivity in HyClone CDM4HEK293 Medium
This application note demonstrates growth and adenovirus productivity of HEK293 cells and explores the key factors involved in the optimization of cell culture performance and scalability.
Cli…
Article
Case Study: Oncolytic Adenovirus Production
This case study describes a robust upstream process and downstream process for oncolytic adenovirus production. Purity of final samples meets regulatory requirements.
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Article
Process Economic Simulation for Scalable Production of Adenovirus
This application note discloses the process economic modelling of a modern start-to-finish adenovirus production process. The novel process was compared with a reference process in both stainless-st…
Article
Gene Therapies Push Viral Vector Production
By Feliza Mirasol
Several virus types have been studied for use as viral vectors in gene therapy, including adenovirus, lentivirus, retrovirus, and adeno-associated virus (AAV). Of these, AA…
Article
2019’s Top Bioprocessing Trends and What to Expect in 2020
Following the high interest in cell and gene therapies, there is a big interest in viral vectors, especially for adeno-associated virus, but also adenovirus. In 2019, a novel production process for ad…