Search results for "Upstream"
Article
QbD and PAT in Upstream and Downstream Processing
UPSTREAM PROCESSING
BioPharm: In implementing QbD, what would you identify as the critical quality attributes (CQAs) in a typical upstream bioprocess using cell-culture?
Vanden Boom (Hospi…
Article
Improving Upstream Predictability
Today, better understanding of cells and how they interact with their environment has enabled improvements in most aspects of upstream processing, from bioreactor design and media development to proce…
Article
Automating Processes in Upstream Processing
BioPharm: What specific challenges do companies face when automating upstream processes?
Marshall: New product introductions into existing facilities often require new equipment process capabiliti…
Article
Maximizing the Effectiveness of Upstream Bioprocessing Through the Combination of Lab Informatics and Instrumentation
By Claire Hill
The biopharmaceutical market continues to expand at a rapid pace and the demand for upstream manufacturing capacity, particularly for growth areas such as viral vectors, is growing …
Article
What’s New in Upstream Technologies
The system features a modular, scalable, fixed-bed bioreactor for enhanced upstream processing of viral products, including viral vaccines, viral vectors, and oncolytic viruses. The low-footprint inte…
Poster
Integration of continuous upstream and downstream operations in mAb production
For a competitive production process, continuous or semi-continuous upstream and downstream processing can be employed. Compared with a process performed in batch runs, continuous processing allows fo…
Article
Upstream PD Time-Saver: Optimize Early
Identify the right combination of culture medium, feed supplements, and feeding strategy early in upstream process development to conserve precious time and resources.
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Article
Upstream, Downstream Processing in Motion
The platform, available globally, incorporates both upstream and downstream steps, including chromatography systems that use fully disposable single-use flow paths, prepacked and prequalified chromato…
Article
Lentiviral Vector Upstream Process in Single-use Bioreactors
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Lentiviruses exhibit many desirable properties as gene transfer vehicles, such as high transduction efficiencies, ability to infect both dividing and nondivi…
Article
Achieving Efficient Adenovirus Upstream Production
Adenovirus is one of the most frequently used viral vectors in the development of therapeutic vaccines and vaccines against infectious diseases. Adenovirus has also been explored as a viral vector f…