Process Development Forum - Insights, Solutions, and Shortcuts in Bioprocessing

Search results for "Upstream"

Article QbD and PAT in Upstream and Downstream Processing
UPSTREAM PROCESSING BioPharm: In implementing QbD, what would you identify as the critical quality attributes (CQAs) in a typical upstream bioprocess using cell-culture? Vanden Boom (Hosp…

Article Automating Processes in Upstream Processing
BioPharm: What specific challenges do companies face when automating upstream processes? Marshall: New product introductions into existing facilities often require new equipment process capabiliti…

Poster Integration of continuous upstream and downstream operations in mAb production
For a competitive production process, continuous or semi-continuous upstream and downstream processing can be employed. Compared with a process performed in batch runs, continuous processing allows fo…

Article Upstream, Downstream Processing in Motion
The platform, available globally, incorporates both upstream and downstream steps, including chromatography systems that use fully disposable single-use flow paths, prepacked and prequalified chromato…

Article Achieving Efficient Adenovirus Upstream Production
Adenovirus is one of the most frequently used viral vectors in the development of therapeutic vaccines and vaccines against infectious diseases. Adenovirus has also been explored as a viral vector f…

Article Unifying Continuous Biomanufacturing Operations
The most efficient upstream processing systems in biologics manufacturing seek to mimic the body’s treatment of cells, so a constant level of incoming nutrients and outgoing waste products is necessar…

Article Continuous Processing for the Production of Biopharmaceuticals
The industry already has experience in terms of continuous upstream processing. Perfusion technology has been successfully used for the production of biotherapeutics for more than a decade. In the pas…

Article The New World of Biopharmaceutical Manufacturing
Single-use technology has also precipitated changes in upstream and downstream processing.  Pharmaceutical Technology spoke with Eric Langer, managing partner at BioPlan Associates; John …

Article Hybrid Bioprocessing: A Q&A with Andrew Sinclair
What could be the main reasons and/or the main drivers that hybrid bioprocessing are being used? Is there a difference between upstream and downstream? If we look at the key benefits that are attr…

Article Continuous Manufacturing: A Changing Processing Paradigm
In addition, there is some trepidation surrounding the integration of upstream and downstream processes and the interaction between unit operations, as it is well documented that changes upstream affe…