Search results for " bispecific"

Article Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
One of these promising groups of antibodies is called bispecifics, where one antibody can simultaneously bind to two targets. Advanced antibody engineering has resulted in the ability to manufactu…

Article FDA Provides Guidance on Bispecific Antibody Development Programs
FDA published final guidance on May 24, 2021 to provide industry and stakeholders with recommendations for the development of bispecific antibodies including recommendations for regulatory, quality, n…

Article Bispecific Antibody Purification: Insights and Case Studies
Here are some industry insights to help you navigate the bispecific jungle. Read Article

Article Single-Step, Protein A Chromatography Process for Bispecific Antibodies in Early Screening
Learn more about bispecific purification

Article Capture of Bispecific Antibodies and Removal of Product-Related Impurities
Many of these variants, especially asymmetric bispecific antibodies, are prone to aggregation or to forming product-related impurities such as homodimers and half antibodies during cell culture. The s…

Article Optimization of a Two-Step Purification Method for Bispecific Antibodies
Alligator and Cytiva developed an efficient downstream purification process for a cancer immunotherapy bispecific antibody (bsAb).  Read more

Article Bispecific Antibodies are Moving from Research to Clinical Development
With recent approvals of bispecific antibodies, these complex molecules are fast moving out of the research box and into clinical pipelines. READ MORE >>

Article Witnessing Major Growth in Next-Generation Antibodies
The global market for next-generation antibodies, including antibody drug conjugates (ADCs), engineered antibodies, bispecific antibodies, antibody fragments, antibody-like proteins and biosimilar ant…

Article A Look at the Affinity Chromatography Landscape
Affinity chromatography for bispecific antibodies Due to the molecular diversity of bispecific antibodies, a general purification platform is not available. A toolbox approach is needed, in which …

Article Advances in Engineering of Protein-Based APIs
Bi/multispecific proteins Bispecific antibodies are an important emerging area in advancing protein engineering for pharmaceutical products, and several bispecifics based on immunoglobulin scaffol…

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