Search results for " wfi"

Article Challenging the cleanroom paradigm for biopharmaceutical manufacturing of bulk drug substances
via U-bend swing connections) or WFI/HPW drops are often made in an open fashion without subsequent sanitization of the connection point. Suggestions for risk mitigation: The flow path could be sa…

Article Economic drivers and trade-offs in antibody purification processes
As increasing titers demand the use of larger downstream equipment or additional cycles, the requirement for buffers and WFI will also increase. In existing facilities, this can present retrofit chall…

Article An Environmental Life Cycle Assessment Comparing Single-Use and Conventional Process Technology
The fuel mix for generation of WFI was composed of different ratios of fuel oil, natural gas and electricity. The default mixture was equally weighted for fuel oil and natural gas at 45% each while el…

Article Fluid Handling in Biopharma Facilities
Kaap (Parker domnick hunter): WFI and buffer solutions, followed by media feed solutions, are generally the largest volume of use in bioprocessing. Single-Use Systems BioPharm: Are single-use s…

Article Concentrating Feed—an Applicable Approach to Improve Antibody Production
After the chemicals were completely dissolved, the medium was made up to the required volume by adding WFI or cell-culture-grade water and filtered through a 0.22-µm filter (Millipore). The medium pH …

Article Improving Process-Scale Chromatography
With ILD, floor space is reduced due to the use of buffer concentrates that are diluted with WFI-grade water as needed. There are issues with this approach, however, according to Ljungqvist. First…

Article Ready-to-use fluid management for inline conditioning (IC) large-scale chromatography systems
…ncreased process efficiencies through the elimination of CIP, steam-in-place (SIP), and reduction of WFI. • Improved cost savings from the reduction in the number and size of chemical storage tan…

Article Make buffer preparation more time and cost efficient with inline conditioning
Simplify Buffer Preparation The volume and number of buffers for a typical downstream process can be considerable. Preparation of these buffers is a challenge that in-line conditioning can …

Article Trends in Single-use Bioreactors
Also, they require far less support hardware--no CIP and SIP is required and WFI demand is significantly reduced Barriers to adoption BioPharm: What are some barriers to single-use bioreactor ad…

Poster In-line buffer conditioning for biopharmaceutical manufacturing
Buffer preparation and handling is a major challenge in industrial biopharmaceutical production. There is a need to decrease costs in labor and space, this need can be met by formulating the buffers…

Next Page