Search results for " cell lines"
Article
Webinar: Establishing a CHO-K1 cell line and cell line development process for biotherapeutics markets
Establishing a robust cell line is a critical step in the development of a biotherapeutic. But how can you meet rapid timelines when the cell line development workflow is challenged by doc…
Article
FDA Seeks to Enhance Manufacturing of Cell and Gene Therapies
He acknowledged that the logistics of manufacturing autologous cells can be particularly challenging, and that limited capacity in cell lines stymie efforts to meet the demand for product development.…
Poster
Benchmarking, scalability, and protein production in CHO cell culture
The most widely used cell lines in the bioprocess industry originate from CHO cells. With the large number of CHO clones in use, it is important to have a cell culture medium that supports high via…
Article
Future-proof your AAV process with a complete producer cell line – just induce and grow
Stable producer cell lines helped to make mAb therapies the powerhouses they are today. To deliver on the promise of AAV-based gene therapy for prevalent diseases, we need similar technology. …
Article
What’s in your media? How costly is variability of cell culture media to your manufacturing process?
Megan Manzano:How do I know what I should be concerned about?
We have customers approach us with concerns and worries and due to different impurities, it can affect different cell lines. W…
Webcast
Establishing a CHO-K1 cell line and cell line development process for biotherapeutics markets
Establishing a robust cell line is a critical step in the development of a biotherapeutic. But how can you meet rapid timelines when the cell line development workflow is challenged by documentation…
Article
Fed-batch supplements to boost cell culture performance
This application note demonstrates the enhanced performance of commonly used cell lines for MAb production when supplemented with HyClone™ cell culture supplements. Cultures of Chinese hamster ovary (…
Article
Optimization of Fed‑Batch Culture Conditions for a mAb‑Producing CHO Cell Line
This application note describes a broadly applicable and efficient workflow toward finding the optimal feed combination for the best-performing fed-batch processes.
An IgG1-producing CHO cell …
Article
Principles of Cell Line Development
This free online course provides an overview of how cell line development plays a critical role in a biotherapeutic drug’s path to market. It also takes a closer look at where it fits int…
Article
Perfusion Culture Using TFF or ATF as Cell Retention Method
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Perfusion processes have many advantages such as being favorable for product quality and supporting efficient facility utilization by offering the possibility…