Search results for " cell lines" in Articles / App Notes
Article
A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
By Luhong He, Christopher Frye
Abstract
The Chinese hamster ovary (CHO) cell lines used for the production of recombinant therapeutic proteins are immortalized cells with a relatively high degre…
Article
Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
Therefore, applicability of this technique is restricted to a limited number of cell lines.
Thermoresponsive substrates have been used to promote the detachment of adhered cells. In this method, t…
Article
Changing the Culture of Cell Culture: Applying Best Practices and Authentication to Ensure Scientific Reproducibility
…ilieu, taking immediate steps to address biological reagent issues--specifically the use of cultured cell lines--is a relatively straightforward fix that will improve the credibility, reproducibility…
Article
Best Practices for Selecting a Top-Quality Cell Line
Defining high-quality cell lines
A high-quality cell line will demonstrate high stability, scalability, and high titer, so that it can provide reproducible results—with all product quality attribu…
Article
The Evolving Role of Starting Materials in Cell and Gene Therapy
The Evolving Role of Starting Materials in Cell and Gene Therapy
Accelerated approval pathways and growing demand for cell and gene therapies are putting pressure on providers of cellular starting m…
Article
Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
Adherent cell lines are the most common choice at early stages of development as they are readily sourced, easy to cultivate at the laboratory scale, and require less expert bioengineering know-how.
…
Article
Mapping a Route for Cell and Gene Therapy Process Development
He points in particular to the avoidance of the use of plasmids and the development of packaging/stable cell lines as current key issues.
Reducing manufacturing costs, as well as development of…
Article
Design Considerations for a Commercial Cell and Gene Therapy Facility
The commercialization of cell and gene therapies has become a reality, prompting deeper considerations of logistics, technology, and design for manufacturing facilities.
By Feliza Mirasol
…
Article
Optimizing your Cell Culture Process to Improve Productivity
It can be applicable to many different cell lines, including CHO or HEK, insect cells, and cell lines used in the cultivated meats industries. Furthermore, we do not need to know anything about the cu…
Article
Implications of Cell Culture Conditions on Protein Glycosylation
The authors present a review of the techniques commonly used for glycosylation analysis.
By Michiel E. Ultee, PhD, Dr. Richard Easton
This article reviews the implications of cell-culture co…