Search results for " fragment"
Article
Antibody Fragments and Their Purification by Protein L Affinity Chromatography
A majority of such molecules are monoclonal antibodies; however, many new entities are antibody fragments. Due to their structural, physiological, and pharmacological properties, antibody fragments of…
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A Platform Approach to Purification of Antibody Fragments
As compared with full length antibodies, their fragments have unique properties that make them favorable for certain therapeutic conditions. However, due to their high molecular diversity, the use of …
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Resolving a bottleneck in screening and characterization of recombinant antibody fragments using Biacore 4000
Biacore 4000 equipped with Biacore 4000 Antibody Extension Package has been used for efficient screening and characterization of antibody fragments for diagnostic purposes. Ten 96-well plates containi…
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Guide for selecting affinity resins for mAbs, bsAbs, and antibody fragments
Today, molecules such as bispecific antibody (bsAb) and antibody fragments such as Fab, scFv, and VHH are seen in labs all over the world. These target molecules need to be purified to reach required …
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Platform for Purification of VHH-type Antibody Fragments
This poster shows examples of purification of mAb-derived fragments.
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Modeling the Degradation of mAb Therapeutics
Different types of chemical instabilities include deamidation, oxidation, fragmentation, and hydrolysis. Although the effects of these instabilities (both physical as well as chemical) may differ amon…
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Analysis of Glycosylation in Biosimilars
Typically, this involves breaking the sample down into its individual monosaccharides, which can be identified and quantified by the retention time and fragmentation pattern using gas chromatography-m…
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Antibody Production in Microbial Hosts
Therapeutic mAbs and their derivatives—such as antibody fragments (Fab), single-chain Fv (scFv), and diabodies—represent the fastest-growing class of approved therapeutic proteins because of their hig…
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Single-Domain Antibodies for Brain Targeting
Smaller recombinant antibody fragments as single-domain antibodies (sdAbs) are emerging as credible alternatives because of their target specificity, high affinity, and cost-effective recombinant prod…
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Addressing the Challenges in Downstream Processing Today and Tomorrow
In the future, mAbs may represent a smaller percentage of the pipeline as portfolios concentrate more on development of antibody fragments, nanobodies, biosimilar protein therapeutics, conjugated prot…