Search results for " filtration" in Articles / App Notes
Article
Register to the Chromatography + Filtration Virtual Summit 2024
Agenda
Day 1:
- Chromatography for antibodies and antibody variants
Day 2:
- Chromatography for recombinant proteins
- Filtration for antibodies and other recombinant proteins
Da…
Article
Filtration methods to overcome new challenges in viral safety
41 and ICH Q5A, and outlines the detailed mechanisms governing effective virus filtration, demonstrating how both specific methods and advanced filter design can overcome these challenges.
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Detailed agenda for Chromatography + filtration virtual summit
Join Cytiva Chromatography and filtration summit online to learn from presentations, live Q&A, and panel discussions on recent advances in antibody, antibody variants, recombinant proteins, and gene t…
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Exosome isolation by tangential flow filtration and size exclusion chromatography
The workflows we describe are suitable for scale-up and combine tangential flow filtration (TFF) for the concentration of exosomes followed by gentle size exclusion chromatography (SEC) with our next-…
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A risk based approach to sterile filtration
Drug quality cannot be assured only by finished-product testing. Process validation is required to establish scientific evidence that a process is capable of delivering an effective and safe …
Article
Challenges in Cell Harvesting Prompt Enhancements
Cell harvesting involves the separation of the cell-culture from the medium and running it through several techniques: centrifugation, microfiltration, depth filtration, and filtration through absolut…
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Downstream Processing for Cell-Based Therapies
Typically, a swing-bucket rotor centrifugation step or a filtration step is included to remove cell debris, large aggregates, unwanted proteins, volume reduce (i.e., concentrate), and formulate the ce…
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Updating Viral Clearance for New Biologic Modalities
Because viruses are typically smaller than downstream impurities such as host cell proteins (HCPs) and other extracellular debris, they require meticulous filtration, even in more established processe…
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Downstream Processing Continues to Worry CMOs
One such step is depth filtration, which has also declined in its own right as a contributor to capacity constraints. This year, 8% of respondents reported at least “significant” constraints due to de…
Article
Selecting a Comprehensive Bioburden Reduction Plan
Filtration
BioPharm: How do endemic bacteria affect the type of filter needed for filtration?
Mittelman and Anicetti (PDA task force): While bacteria (and fungi) may be present in all in-proce…