Search results for " ATF"

Article Perfusion Culture Using TFF or ATF as Cell Retention Method
Perfusion processes have many advantages such as being favorable for product quality and supporting efficient facility utilization by offering the possibility of using smaller bioreactors. Compared …

Article Unifying Continuous Biomanufacturing Operations
…d with tangential-flow filtration (TFF), comments Morbidelli, although he says the scale-up for both ATF and TFF remains, to a certain extent, an open issue. Bonham-Carter notes that using ATF for ce…

Article Tools for Continuous Bioprocessing Development
External hollow-fiber systems such as the ATF and TFF couple hollow-fiber filters to a conventional bioreactor. These systems circulate cells between the conventional bioreactor and the hollow fibers …

Article Achieving Process Balance with Perfusion Bioreactors
Sartorius Stedim Biotech is working with Repligen to develop integration of the Repligen ATF system into the Sartorius bioreactor with respect to both process control and consumables, according to Ada…

Article Perfusion in the 21st Century
Quality, flexibility, and cost savings are driving use of perfusion technology in biosimilars manufacturing. By Bruce Lehr, Delia Lyons Cell-culture technology for biopharmaceutical manufact…

Article Continuous Processing for the Production of Biopharmaceuticals
The authors review the technologies that may help bioprocessing become a truly continuous operation and present case studies that could contribute to the integration of upstream and downstream platf

Article Continuous Manufacturing: A Changing Processing Paradigm
Apr 01, 2015 By Randi Hernandez BioPharm International Volume 28, Issue 4 Although continuous manufacturing is well established for bulk chemicals, complex automation and validation …