Search results for " PrismA" in Articles / App Notes

Article Process Economy Simulations on a Protein A Capture Step
This application note gives calculation examples that highlight scenarios where the enhanced capacity and alkaline‐stability of MabSelect PrismA can provide process economic benefits to large‐scal…

Article Rapid Cycling Protein A-Based Fiber Chromatography to Address Emerging Downstream Bottlenecks
Fibro PrismA is a new protein A fiber chromatography format developed to complement traditional resin-based chromatography. The protein A fiber matrix has an open pore structure in which mass transf…

Article Capacity and Performance of a Next Generation Protein A Chromatography Resin
This application note demonstrates the binding capacity and purification performance of MabSelect PrismA in comparison with its predecessor products for both polyclonal and monoclonal antibodies. An i…

Article Speeding Up mAb Purification Using Fiber-based Technology
Read more on high throughput automated mAb purification using HiTrap Fibro PrismA.

Article Multidimensional Scale-Up of a Monoclonal Antibody Capture Step, Using ÄKTA™ pilot 600
The process, performed with MabSelect™ PrismA Protein A chromatography resin, was scaled up 20-fold from a 70 mL HiScale™ 26 column to a 1400 mL AxiChrom™ 100 column. Equivalent mAb recovery and purit…

Article Development and Future of Protein A Chromatography Technology: Q&A with Jonathan Royce, Business Leader Chromatography Resins, GE Healthcare
Several years ago, we started a development project to design and validate the next-generation protein A resin, MabSelect PrismA, which was just introduced to the market. Now, 1M NaOH can in fact be u…

Article Next Generation Process Chromatography
Hardick: With HiTrap™ Fibro PrismA now launched for R&D applications, the teams are working hard to ensure this is followed soon by the launch of the GMP units capable of purifying up to 15-kg mAb in …

Article Case Study: High Throughput mAb Purification Using Fibro
In this case study, a drug discovery lab at AstraZeneca finds that purifying antibodies with Fibro PrismA means they can screen more candidates per week with a simpler equipment setup. Click here…

Article Case Study: Virus Reduction of an Affinity Capture Step
Evaluating how much a process step contributes to viral clearance is an essential part of process validation. For this reason, there is an industry need to perform effective viral clearance studies. I…

Article Single-Step, Protein A Chromatography Process for Bispecific Antibodies in Early Screening
MabSelect™ PrismA protein A resin was selected for the capture step. Most fragments could be removed as early as the capture step using gradient elution from pH 5 to 3.5, without the need for addition…

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