Search results for " host cell protein"

Article A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
The authors describe the ways in which manufacturers can mitigate the risks related to the integrity of recombinant transgenes expressed in CHO cells. By Luhong He, Christopher Frye Abstract …

Article Best Practices for Selecting a Top-Quality Cell Line
Irina Shi - Stock.Adobe.com Leveraging automation and a step-by-step approach are keys to success. By Cynthia A. Challener Cell lines determine the performanc…

Article Scale-up of adherent Vero cells grown on Cytodex microcarrierrs using ReadyToProcess equipment
In cell culture-based vaccine production, scale-up of adherent cells is challenging. This study shows a process for scaling up adherent Vero cells from static cell factories to influenza producti…

Article The Evolving Role of Starting Materials in Cell and Gene Therapy
The Evolving Role of Starting Materials in Cell and Gene Therapy Accelerated approval pathways and growing demand for cell and gene therapies are putting pressure on providers of cellular starting m…

Article Implications of Cell Culture Conditions on Protein Glycosylation
The authors present a review of the techniques commonly used for glycosylation analysis. By Michiel E. Ultee, PhD, Dr. Richard Easton This article reviews the implications of cell-culture co…

Poster Host Cell Proteins beyond ELISA with label free interaction and imaging technologies
This technology was used to characterize the effect of different culture conditions on MAb expressing CHO cells in terms of almost 1700 individual host cell protein profiles and overall patterns in ha…

Resource Challenging Host Cell Protein Assays for Improved Risk Mitigation
This webinar shares Cytiva’s strategy for designing a comprehensive host cell protein (HCP) risk mitigation strategy. We will address how to challenge your assays early to ensure accurate measurements…

Article New Webinar: Challenging Host Cell Protein Assays for Improved Risk Mitigation
Watch webinar >> This webinar shares Cytiva’s strategy for designing a comprehensive host cell protein (HCP) risk mitigation strategy. We will address how to challenge your assays early to ensur…

Resource Challenges of Host Cell Protein Analysis with ELISA and How to Obtain Better Coverage of Your ELISA
Host cell protein (HCP) is a significant class of process-related impurity that needs to be removed to adequately low levels during the manufacturing of biological products to ensure product purity …

Poster Sensitive methods for evaluation of antibodies for host cell protein analysis and screening of impurities in a vaccine process
An evaluation of the affinity spectra of HCP antibodies purified from rabbits immunized with Vero cell lysate, using two different adjuvants: FCA and AbISCO®.

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