Search results for " chromatography"

Article Making the Move to Continuous Chromatography
Some regulatory aspects must still be addressed, however, and for companies with extensive existing infrastructure, switching to continuous chromatography might not be cost-effective. Continuous vs…

Article Improving Process-Scale Chromatography
Advances are being made on several fronts to reduce the time and cost associated with large-scale chromatography. The development of new resin chemistries including enhancements to Protein A for monoc…

Article Process Chromatography Selection for Downstream Processing Applications
By Caroline Hroncich Process chromatography has changed significantly since it was first introduced to the biopharmaceutical industry. Important factors such as column design, resin development, a…

Article Process Chromatography: Continuous Optimization
A combination of chromatography steps using different resin chemistries is used to purify the biologic drug substance to an acceptable level. The number and types of chromatography steps depend on the…

Article Reducing Cross-Contamination Risks in Process Chromatography
Single-use solutions for process chromatography are no exception and offer distinct advantages over permanent, stainless-steel systems in many circumstances. Reducing risk Manufacturers…

Article Optimizing Resin Performance with Disposable Chromatography Solutions
…y, vice-president of sales and marketing, bioprocessing, Repligen about current trends in disposable chromatography and how the technology will change bioprocessing in the future. The experts address…

Article HT Multi-Product Liquid Chromatography for Characterization of Monoclonal Antibodies
This article discusses recent advances in high-throughput and multi-product liquid chromatography and electrophoretic methods for protein characterization. In addition to advances in analytical method…

Article Mixed-Mode Chromatography in Downstream Process Development
By Felix Oehme, PhD, and Joerg Peters, PhD ABSTRACT Mixed-mode chromatography materials contain ligands of multimodal functionality that allow protein adsorption by a combination of ionic interac…

Article Mechanistic Modeling of Preparative Ion-Exchange Chromatography
However, development and optimization of a process chromatography step presents a major challenge due to the large number of process parameters that can affect the performance of the step. For example…

Article Continuous Chromatography: Trends, Definitions and Approaches
There is a lot of attention being paid to continuous chromatography, and several different terms are being used: SMB, PCC, MCC. What is your view on the terminology? Is there a difference among them? …

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